https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30417 Wed 11 Apr 2018 10:16:02 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23883 P-value=3.12 x 10^-8) and in the joint discovery and replication meta-analysis (P-value=3.28 x 10^-9 after adjustment for age, gender and education) in an intron of the gene cell adhesion molecule 2 (CADM2) for performance on the LDST/DSST. Rs17518584 is located about 170 kb upstream of the transcription start site of the major transcript for the CADM2 gene, but is within an intron of a variant transcript that includes an alternative first exon. The variant is associated with expression of CADM2 in the cingulate cortex (P-value=4 x 10^-4). The protein encoded by CADM2 is involved in glutamate signaling (P-value=7.22 x 10^-15), gamma-aminobutyric acid (GABA) transport (P-value=1.36 x 10^-11) and neuron cell-cell adhesion (P-value=1.48 x 10^-13). Our findings suggest that genetic variation in the CADM2 gene is associated with individual differences in information processing speed.]]> Thu 13 Jan 2022 10:29:45 AEDT ]]>